Maenaut K, Westhovens R, Dequeker J
Department of Internal Medicine, K. U. Leuven, Pellenberg, Belgium.
J Rheumatol. 1996 Dec;23(12):2156-9.
We describe 2 postmenopausal women with rheumatoid arthritis (RA). They developed fractures during their treatment with weekly low dose methotrexate (MTX). The adverse effect of longterm low dose regimens of MTX on bone metabolism has been described as "methotrexate osteopathy," an analogy of the syndrome known in pediatric oncology. MTX may be an additional risk factor for osteoporosis and fractures in RA. This therapy should be relatively contraindicated in patients with multiple risk factors for osteoporosis.
我们描述了2例患有类风湿关节炎（RA）的绝经后女性。她们在接受每周低剂量甲氨蝶呤（MTX）治疗期间发生了骨折。长期低剂量MTX方案对骨代谢的不良影响被描述为“甲氨蝶呤骨病”，这类似于儿科肿瘤学中已知的综合征。MTX可能是RA患者骨质疏松和骨折的一个额外危险因素。对于有多种骨质疏松危险因素的患者，这种治疗应相对禁忌。
