Jonas M, Brandau W, Vollet B, Weyand M, Fahrenkamp A, Gildehaus F J, Sciuk J, Scheld H H, Schober O
Department of Nuclear Medicine, Westfälische Wilhelms University of Münster, Germany.
J Nucl Med. 1996 Dec;37(12):1990-4.
The biodistribution of the fatty acid analog [131I]PHIPA 3-10, was compared to the flow tracer 99mTc-sestamibi by quantitative analysis in a dual-isotope study performed during a heart transplantation.
Iodine-131-PHIPA 3-10 and 99mTc-sestamibi were injected simultaneously approximately 20 min prior to the start of surgical procedure. Scintigraphic images of the sliced explanted heart were compared to the preoperative in vivo scans using [123I]PHIPA 3-10, 201TI and 99mTc-sestamibi. In 14 tissue samples of the explanted heart, the radioactive contents from [131I]PHIPA 3-10 and 99mTc-sestamibi were calculated as %ID/g-values and correlated with the corresponding histology.
In the preoperative scans, a mismatch of fatty acid uptake and perfusion ([123I]PHIPA 3-10 > flow) was observed which indicated residual viable myocardium, while a matched defect was associated with scar. In viable myocardium, there was a significantly higher accumulation of [131I]PHIPA 3-10 compared to 99mTc-sestamibi (mean 5.9 x 10(-3) versus 2.7 x 10(-3)%ID/g),whereas in scars the uptake of both tracers was comparable (1.2 x 10(-3) versus 1.4 x 10(-3)%ID/g).
Myocardial viability can be defined more accurately with radioiodinated PHIPA 3-10 than with 99mTc-sestamibi. The differences of biodistribution in viable myocardium and scars indicate that not only perfusion but also the metabolic state of the myocardium can be evaluated with radioiodinated PHIPA 3-10.
在心脏移植期间进行的双同位素研究中，通过定量分析比较了脂肪酸类似物[131I]PHIPA 3 - 10与血流示踪剂99mTc - 司他米比的生物分布。
在手术开始前约20分钟同时注射碘 - 131 - PHIPA 3 - 10和99mTc - 司他米比。将切下的离体心脏的闪烁图像与术前使用[123I]PHIPA 3 - 10、201铊和99mTc - 司他米比进行的体内扫描进行比较。在14个离体心脏组织样本中，计算[131I]PHIPA 3 - 10和99mTc - 司他米比的放射性含量，以%ID/g值表示，并与相应的组织学结果相关联。
在术前扫描中，观察到脂肪酸摄取与灌注不匹配（[123I]PHIPA 3 - 10>血流），这表明存在存活心肌，而匹配的缺损与瘢痕有关。在存活心肌中，[131I]PHIPA 3 - 10的蓄积明显高于99mTc - 司他米比（平均分别为5.9×10⁻³与2.7×10⁻³%ID/g），而在瘢痕中，两种示踪剂的摄取相当（1.2×10⁻³与1.4×10⁻³%ID/g）。
与99mTc - 司他米比相比，放射性碘化的PHIPA 3 - 10能更准确地定义心肌活力。存活心肌和瘢痕中生物分布的差异表明，放射性碘化的PHIPA 3 - 10不仅可以评估灌注，还可以评估心肌的代谢状态。
