Russell S R
Department of Genetics, University of Cambridge, U.K.
Biochem Soc Symp. 1996;62:111-21.
In Drosophila several members of the nuclear hormone receptor super-family are involved in regulating developmental pathways mediated by the steroid hormone ecdysone. At least seven genes encode a set of receptors which are expressed in a complex overlapping temporal and tissue-specific pattern. The variety of Drosophila receptors invites comparisons with mammalian systems and suggests that different receptors may interact to regulate developmental decisions. Once again the humble fruit fly is providing a genetic framework for understanding complex regulatory systems which have been conserved during evolution.
在果蝇中，核激素受体超家族的几个成员参与调控由类固醇激素蜕皮激素介导的发育途径。至少有七个基因编码一组受体，这些受体以复杂的、相互重叠的时间和组织特异性模式表达。果蝇受体的多样性促使人们将其与哺乳动物系统进行比较，并表明不同的受体可能相互作用以调节发育决策。不起眼的果蝇再次为理解进化过程中保守的复杂调控系统提供了一个遗传框架。
