Johnson F L
Division of Pediatric Hematology/Oncology, Oregon Health Sciences University, Portland 97201-3098, USA.
Bone Marrow Transplant. 1996 Dec;18 Suppl 3:S39-44.
The most effective treatment currently available for children with severe aplastic anemia is bone marrow transplantation using a sibling donor who is completely matched with the patient at the major histocompatibility complex. Only a minority of patients, however, will have such a donor and other treatments which have been used include the use of single agent immunosuppression, multi-agent immunosuppression, multi-agent immunosuppression with hemopoietic growth factors, and the use of allogeneic stem cell transplantation using mismatched family members, unrelated individuals or placental blood. Of these approaches the most promising appears to be the use of combination immunosuppressive therapy plus hemopoietic growth factors. This paper reviews the current results obtained in using these various methods of treating children with severe aplastic anemia who lack a matched sibling donor.
目前，对于患有严重再生障碍性贫血的儿童，最有效的治疗方法是使用在主要组织相容性复合体上与患者完全匹配的同胞供体进行骨髓移植。然而，只有少数患者会有这样的供体，其他已使用的治疗方法包括使用单一药物免疫抑制、多药物免疫抑制、联合造血生长因子的多药物免疫抑制，以及使用不匹配的家庭成员、无关个体或胎盘血进行异基因干细胞移植。在这些方法中，最有前景的似乎是联合免疫抑制疗法加造血生长因子的使用。本文综述了使用这些不同方法治疗缺乏匹配同胞供体的严重再生障碍性贫血儿童所取得的当前结果。
