土耳其人群中氯胍代谢与S-美芬妥因氧化的关系。
Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population.
作者信息
Basci N E, Bozkurt A, Kortunay S, Isimer A, Sayal A, Kayaalp S O
机构信息
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
出版信息
Br J Clin Pharmacol. 1996 Dec;42(6):771-3. doi: 10.1046/j.1365-2125.1996.00500.x.
The oxidation of proguanil was studied in 89 unrelated healthy Turkish volunteers after administration of proguanil (single dose, 200 mg, orally). Based on the distribution of the ratio of proguanil to cycloguanil excreted in urine, and using an antimode value of 15, the prevalence of poor metabolizers in a Turkish population was estimated to be 5.6% (95% confidence interval 2.0%-17.3%) which was similar to that in the other Caucasian populations. The relationship between the oxidative capacities of CYP2C19 for the two substrates, proguanil and mephenytoin, was studied in 39 subjects (two poor and 37 extensive metabolizers of proguanil). The two poor metabolizers of proguanil were also identified as poor metabolizers of S-mephenytoin and no misclassification by the two phenotyping methods was observed. The correlation between the metabolic ratio of proguanil to cycloguanil and the S/R-mephenytoin ratio as assessed by Spearman's rank test, was statistically significant (rs = 0.50, P < 0.001).
在89名无亲缘关系的健康土耳其志愿者口服单剂量200 mg氯胍后，对氯胍的氧化情况进行了研究。根据尿中排泄的氯胍与环氯胍的比例分布，并以反众数15为界值，估计土耳其人群中代谢缓慢者的患病率为5.6%（95%置信区间2.0%-17.3%），这与其他高加索人群相似。在39名受试者（2名氯胍代谢缓慢者和37名氯胍代谢正常者）中研究了CYP2C19对氯胍和甲妥英这两种底物的氧化能力之间的关系。这两名氯胍代谢缓慢者也被鉴定为S-甲妥英代谢缓慢者，且未观察到两种表型分析方法出现错误分类。通过Spearman秩检验评估，氯胍与环氯胍的代谢率和S/R-甲妥英比例之间的相关性具有统计学意义（rs = 0.50，P < 0.001）。
Zotero 插件