Brummer R J, Lönn L, Bengtsson B A, Kvist H, Bosaeus I, Sjöström L
Department of Clinical Nutrition, Sahlgrenska Hospital, Göteborg, Sweden.
Growth Regul. 1996 Dec;6(4):191-200.
The aberrant body composition of 10 patients with active acromegaly was used to evaluate the validity and limitations of several models and methods to assess body composition. Body composition was determined using either a two-compartment model, dividing the body in a body fat (BF) compartment and a fat-free mass (FFM) compartment, or a four-compartment model in which the FFM compartment comprises the three following components: body cell mass, extracellular water and the fat-free extracellular solids. The measurement techniques consisted of anthropometry, bioelectrical impedance analysis (BIA)-applying various established regression equations-tritiated water dilution, whole body 40K-counting, and whole body computed tomography (CT). This latter method was used as the reference technique. Assessment of total body water using BIA - applying the RJL or Kushner equation-correlated significantly with the assessment using tritiated water dilution (P < 0.01). Body fat assessment using the two-compartment model based on either tritiated water dilution or BIA-applying the RJL or Lukaski equation-as well as body fat assessment using the four-compartment model based on tritiated water dilution and whole body 40K-counting were significantly correlated with body fat assessment using CT (P < 0.01) and resulted in good agreement with each other with respect to the absolute values of the body fat determination. BIA using other regression equations overestimated body fat by 7.2-13.7 kg. Whole body 40K-counting was significantly correlated with CT-determined muscle plus skin volume (P < 0.001). CT-calibrated anthropometric predictions significantly overestimated body fat. It is concluded that in patients with active acromegaly, the determination of body composition using either certain two-compartment models based on measurement of total body water or bioelectrical impedance, or a four-compartment model based on total body water and total body potassium measurements show good agreement with CT-determined body composition.
选取10例活动期肢端肥大症患者的异常身体成分，以评估多种评估身体成分的模型和方法的有效性及局限性。身体成分的测定采用两室模型，即将身体分为体脂（BF）室和去脂体重（FFM）室，或四室模型，其中FFM室包括以下三个成分：体细胞群、细胞外液和去脂细胞外固体。测量技术包括人体测量学、生物电阻抗分析（BIA）——应用各种既定回归方程——氚水稀释法、全身40K计数法和全身计算机断层扫描（CT）。后一种方法用作参考技术。使用BIA——应用RJL或库什纳方程——评估总体水与使用氚水稀释法评估总体水显著相关（P<0.01）。使用基于氚水稀释法或BIA——应用RJL或卢卡斯方程——的两室模型评估体脂，以及使用基于氚水稀释法和全身40K计数法的四室模型评估体脂，均与使用CT评估体脂显著相关（P<0.01），并且在体脂测定的绝对值方面彼此之间具有良好的一致性。使用其他回归方程的BIA高估体脂7.2 - 13.7千克。全身40K计数与CT测定的肌肉加皮肤体积显著相关（P<0.001）。CT校准的人体测量学预测显著高估了体脂。得出的结论是，在活动期肢端肥大症患者中，使用基于总体水测量或生物电阻抗的某些两室模型，或基于总体水和全身钾测量的四室模型来测定身体成分，与CT测定的身体成分显示出良好的一致性。
