Elliott J L, Oldham J M, Asher G W, Molan P C, Bass J J
Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.
Growth Regul. 1996 Dec;6(4):214-21.
Testosterone regulation of antler growth may be via the insulin-like growth factors (IGFs). Using histological autoradiography we have measured the specific binding of IGF-I and IGF-II to antler sections during normal growth and during the maturation which follows testosterone treatment of adult fallow deer. In antlers from 20 to 100 days following casting, IGF-I binding was constant within each histological region until 80 days. Between this time and 100 days there was decreased binding to chondrocytes (P < or = 0.01) and increased binding to the reserve mesenchyme/perichondrium (P < or = 0.001). Following testosterone treatment, IGF-I binding declined in dermis (P < or = 0.05), reserve mesenchyme/perichondrium (P < or = 0.05), and chondroblasts (P < or = 0.01). Specific binding of IGF-II showed no change during normal or testosterone-stimulated growth. In conclusion, the regulation of antler maturation by testosterone may include IGF action, probably via the Type 1 IGF receptor.
睾酮对鹿茸生长的调节可能是通过胰岛素样生长因子（IGFs）实现的。我们采用组织学放射自显影法，测定了成年黇鹿在正常生长期间以及睾酮处理后的成熟过程中，IGF-I和IGF-II与鹿茸切片的特异性结合情况。在脱角后20至100天的鹿茸中，直至80天，每个组织学区域内的IGF-I结合保持恒定。在此期间至100天之间，软骨细胞的结合减少（P≤0.01），而储备间充质/软骨膜的结合增加（P≤0.001）。睾酮处理后，真皮（P≤0.05）、储备间充质/软骨膜（P≤0.05）和成软骨细胞（P≤0.01）中的IGF-I结合下降。IGF-II的特异性结合在正常生长或睾酮刺激的生长过程中均未显示出变化。总之，睾酮对鹿茸成熟的调节可能包括IGF的作用，可能是通过1型IGF受体介导的。
