肾移植受者中输血传播疾病的患病率。

The prevalence of transfusion transmitted diseases in renal transplant recipients.

作者信息

Choudhury N, Naik S, Sharma R K, Elhence P, Ramesh V, Gupta R K

机构信息

Deptt. of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.

出版信息

Indian J Pathol Microbiol. 1996 Jul;39(3):191-5.

PMID:8972147

Abstract

Majority of renal transplant patients have history of blood transfusion. Out of a total of 120 renal transplant patients, 20 (16.6%) patients showed raised alanine aminotransferase (ALT) levels (> 45 IU) on 2 or more occasions at 2 weeks interval. This study was undertaken to estimate the risk of transfusion transmitted diseases (TTD) in these 20 renal transplant patients. Another 200 voluntary blood donors were also included as control. Both subject groups were screened by ELISA for HBsAg, anti HBc (IgG & IgM), anti HCV, anti CMV (IgM), anti HIV and VDRL tests for syphilis. A total of 11 (55%) patients and 3 (1.5%) blood donors showed the evidence of HBsAg positivity (p < 0.01). Anti HBc antibody was present in 12 (60%) patients and 39 (19.5%) donors which was significantly (p < 0.01) different. Anti HCV antibody was detected in 5 patients and in one blood donor (p < 0.01). However, anti CMV antibody was present in 4 (20%) patients and 3 (1.5%) donors, respectively. There was no evidence of HIV and syphilis infection in both these groups. High incidence of hepatitis markers were observed in renal transplant patients.

摘要

大多数肾移植患者有输血史。在总共120例肾移植患者中，20例（16.6%）患者在2周间隔内2次或更多次出现丙氨酸转氨酶（ALT）水平升高（>45 IU）。本研究旨在评估这20例肾移植患者中输血传播疾病（TTD）的风险。另外200名自愿献血者也作为对照纳入研究。两组受试者均通过酶联免疫吸附测定（ELISA）检测乙肝表面抗原（HBsAg）、抗乙肝核心抗体（抗HBc，IgG和IgM）、抗丙型肝炎病毒抗体（抗HCV）、抗巨细胞病毒抗体（抗CMV，IgM）、抗人类免疫缺陷病毒抗体（抗HIV）以及梅毒血清学试验（VDRL）。共有11例（55%）患者和3例（1.5%）献血者出现HBsAg阳性证据（p<0.01）。12例（60%）患者和39例（19.5%）献血者存在抗HBc抗体，差异有统计学意义（p<0.01）。5例患者和1例献血者检测到抗HCV抗体（p<0.01）。然而，抗CMV抗体分别在4例（20%）患者和3例（1.5%）献血者中出现。两组均无HIV和梅毒感染证据。肾移植患者中肝炎标志物的发生率较高。