Lange A P, Secher N J
Prostaglandins. 1977 Aug;14(2):389-95. doi: 10.1016/0090-6980(77)90184-8.
Abortion was successfully induced in 79 of 80 patients in midtrimester, by the serial administration of 250 microgram of 15 (S)-15 methyl PGF2alpha intramuscularly every second hour until abortion occurred. All 12 patients with missed abortion and 87% of the legal abortion patients aborted within 24 hours. The average period until abortion occurred in the missed abortion group was 8.2 hours (+/- 4.5 SD), and in the legal abortion group 16.4 hours (+/- 7.3 SD). All the patients were given prophylactic treatment for vomiting, using prochlorperazine. The average number of episodes of vomiting was 2.8 per ptient. All but 3 patients were given loperamide or diphenoxylate for "diarrhoea". The average number of episodes of diarrhoea was 2.5 per patient. The frequency of complications was low apart from a case of low uterine rupture.
在妊娠中期的80例患者中，79例通过每隔两小时肌肉注射250微克15（S）-15甲基前列腺素F2α直至流产成功诱导流产。12例稽留流产患者和87%的合法流产患者均在24小时内流产。稽留流产组流产发生的平均时间为8.2小时（±4.5标准差），合法流产组为16.4小时（±7.3标准差）。所有患者均使用氯丙嗪进行止吐预防性治疗。每位患者呕吐发作的平均次数为2.8次。除3例患者外，所有患者均因“腹泻”给予洛哌丁胺或地芬诺酯。每位患者腹泻发作的平均次数为2.5次。除1例子宫下段破裂外，并发症发生率较低。
