Puza S, Malee M P
Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, USA.
J Matern Fetal Med. 1996 Nov-Dec;5(6):328-32. doi: 10.1002/(SICI)1520-6661(199611/12)5:6<328::AID-MFM7>3.0.CO;2-R.
Thrombotic thrombocytopenic purpura (TTP) is a disorder of unknown etiology affecting the microcirculation of multiple organ systems. Plasma therapy has significantly reduced the mortality rate; thus, an increased incidence of recurrence has been noted. Since corticosteroids, antiplatelet agents, and splenectomy do not prevent recurrences, monthly plasma infusion have been instituted to decrease the risk of recurrence. However, in pregnancy, increase in frequency of plasma infusions to weekly or biweekly intervals has been associated with avoidance of placental infarcts. This is the first report of a successful pregnancy in which bimonthly prophylactic single plasma-exchange plasmapheresis was the treatment regimen with no obvious maternal-fetal morbidity.
血栓性血小板减少性紫癜（TTP）是一种病因不明的疾病，影响多个器官系统的微循环。血浆疗法显著降低了死亡率；因此，复发率有所上升。由于皮质类固醇、抗血小板药物和脾切除术不能预防复发，已开始每月进行血浆输注以降低复发风险。然而，在妊娠期，将血浆输注频率增加至每周或每两周一次与避免胎盘梗死有关。这是首例成功妊娠的报告，其中每两个月进行一次预防性单次血浆置换血浆分离术作为治疗方案，且无明显母婴并发症。
