Overstreet D H, Rezvani A H
Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill 27599-7178, USA.
Psychopharmacology (Berl). 1996 Dec;128(3):328-30. doi: 10.1007/s002130050141.
The Fawn-Hooded rat (FH) strain has attracted the attention of some psychopharmacologists because of reports of its exaggerated immobility in the swim test, hypercortisolemia, excessive voluntary intake of alcohol, platelet and central serotonin abnormalities and subsensitivity to serotonergic agonists. However, there appears to be some controversy over several behavioral and physiological characteristics of these rats. The present paper proposes that the lack of reproducible findings can be traced to there being several distinct inbred strains of FH rats. Of the two compared in this communication, the FH/Wjd strain is more immobile in the forced swim test, spends more time in the open arms of the elevated plus maze, and drinks more saccharin and alcohol voluntarily than the FH/Har (Iowa Reactive) strain. Future workers are cautioned to report the source of their FH rats.
小鹿斑鼠（FH）品系因其在游泳试验中表现出夸张的不动性、高皮质醇血症、自愿过量摄入酒精、血小板和中枢血清素异常以及对血清素能激动剂反应迟钝等报道，引起了一些精神药理学家的关注。然而，这些大鼠的一些行为和生理特征似乎存在一些争议。本文提出，缺乏可重复的研究结果可追溯到存在几种不同的FH大鼠近交系。在本交流中比较的两个品系中，FH/Wjd品系在强迫游泳试验中更不动，在高架十字迷宫的开放臂中停留的时间更长，并且比FH/Har（爱荷华反应性）品系自愿饮用更多的糖精和酒精。提醒未来的研究人员报告他们所用FH大鼠的来源。
