Di Stefano A, La Gaetana R, Bovalini L, Lusini P, Martelli P
Department of Molecular Biology, University of Siena, Italy.
Biochim Biophys Acta. 1996 Nov 8;1314(1-2):105-8. doi: 10.1016/s0167-4889(96)00084-5.
Khellin, a furochromone structurally related to furocoumarins, is a phototherapeutic agent used against psoriasis and vitiligo. This paper reports that pretreatment of HeLa cells with pertussis toxin reverses both the inhibition of NaF-stimulated adenylyl cyclase activity and the stimulation of GTPase by khellin alone and plus UVA light, as previously reported. Our results demonstrate, for the first time, that khellin is able to elicit an intracellular response by Gi alpha protein.
凯林是一种与呋喃香豆素结构相关的呋喃色原酮，是一种用于治疗牛皮癣和白癜风的光疗药物。本文报道，如先前报道的那样，用百日咳毒素预处理HeLa细胞可逆转单独使用凯林以及凯林加紫外线A光对氟化钠刺激的腺苷酸环化酶活性的抑制作用和对GTP酶的刺激作用。我们的结果首次证明，凯林能够通过Giα蛋白引发细胞内反应。
