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Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function.

作者信息

Kalkbrenner F, Dippel E, Wittig B, Schultz G

机构信息

Institut für Pharmakologie, Freie Universität Berlin, Germany. fkalkbr.fu-zedat.berlin.de

出版信息

Biochim Biophys Acta. 1996 Nov 8;1314(1-2):125-39. doi: 10.1016/s0167-4889(96)00072-9.

DOI:10.1016/s0167-4889(96)00072-9
PMID:8972726
Abstract
摘要

相似文献

1
Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function.受体与G蛋白之间相互作用的特异性:运用反义技术将G蛋白亚基与功能联系起来。
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2
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3
Specific inhibition of receptor-dependent human cellular responses by antisense mRNA depletion of individual G-proteins.通过单个G蛋白的反义mRNA耗竭对受体依赖性人类细胞反应进行特异性抑制。
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Specificity and complexity of receptor-G-protein interaction.
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Dissecting G-protein-coupled receptors: structure, function, and ligand interaction.剖析G蛋白偶联受体:结构、功能及配体相互作用
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Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex.受体 - G蛋白偶联是通过βγ复合体中潜在的构象转换建立的。
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引用本文的文献

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Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) alpha and betagamma subunits by urea.通过尿素对鸟嘌呤核苷酸结合调节蛋白(G蛋白)α亚基和βγ亚基进行选择性失活。
Biochem J. 2001 Mar 1;354(Pt 2):337-44. doi: 10.1042/0264-6021:3540337.
2
Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons.G蛋白异源三聚体组成对交感神经元中神经递质受体与N型Ca(2+)通道调制偶联的影响。
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):907-12. doi: 10.1073/pnas.97.2.907.
3
Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig.
Gi蛋白α亚基mRNA反义寡核苷酸对豚鼠附睾中Gi偶联受体收缩活性的抑制作用
Br J Pharmacol. 1999 May;127(1):85-90. doi: 10.1038/sj.bjp.0702515.
4
Sequestration of G-protein beta gamma subunits by different G-protein alpha subunits blocks voltage-dependent modulation of Ca2+ channels in rat sympathetic neurons.不同的G蛋白α亚基对G蛋白βγ亚基的隔离作用会阻断大鼠交感神经元中Ca2+通道的电压依赖性调节。
J Neurosci. 1999 Jun 15;19(12):4755-61. doi: 10.1523/JNEUROSCI.19-12-04755.1999.
5
Mechanisms of modulation of voltage-dependent calcium channels by G proteins.G蛋白对电压依赖性钙通道的调节机制。
J Physiol. 1998 Jan 1;506 ( Pt 1)(Pt 1):3-11. doi: 10.1111/j.1469-7793.1998.003bx.x.
6
The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles.异源三聚体G蛋白Go2通过分泌囊泡调节儿茶酚胺摄取。
EMBO J. 1998 Jan 15;17(2):406-13. doi: 10.1093/emboj/17.2.406.
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Receptors couple to L-type calcium channels via distinct Go proteins in rat neuroendocrine cell lines.在大鼠神经内分泌细胞系中,受体通过不同的Go蛋白与L型钙通道偶联。
J Physiol. 1997 Jul 15;502 ( Pt 2)(Pt 2):321-33. doi: 10.1111/j.1469-7793.1997.321bk.x.