Joshi P L, Bhattacharya M, Yadava R L, Chand B, Narasimham M V, Nigam D K, Jain C L
Regional Office for Health and Family Welfare, Lucknow.
J Commun Dis. 1996 Sep;28(3):189-98.
The study was carried out in Allahabad district, (Uttar Pradesh) with 260 spraymen as test subjects and 50 persons as controls from a sprayed and unsprayed village respectively. Majority of the spraymen (44%) had worked for 3-4 years (seasons) and 31% had worked in the programme for 5-10 years. The spraymen were relatively healthy with no complaints in 77% whereas the figures were 76% for the Community living in the sprayed village, and 50% for the Community in the unsprayed village. A comparison of the biochemical parameters revealed lowered Cholesterol more than 150 mg % in 38% of the spraymen and 58% had altered A:G ratio. Other biochemical estimations were not significantly different from the control population. The mean residue of Alpha, Beta and Gamma Isomers and the total Alpha, Beta and Gamma isomers were 0.0317, 0.2254, 0.0288 and 0.2859 mg/1 respectively; the corresponding mean values in the control population were 0.0211, 0.1112, 0.0197 and 0.1520 mg/1 respectively. The values in spraymen were twice those of the general population. A significant association (p < .05) was observed between their length of exposure and the levels of Cholesterol and HCH isomers in blood of spraymen. No significant morbidity was evident in spraymen due to HCH exposure.
该研究在北方邦的阿拉哈巴德地区开展，以260名喷雾器操作人员作为试验对象，分别从一个喷洒过农药和未喷洒过农药的村庄选取50人作为对照。大多数喷雾器操作人员（44%）工作了3至4年（季节），31%在该项目中工作了5至10年。喷雾器操作人员相对健康，77%没有不适主诉；而在喷洒过农药的村庄居住的人群中这一比例为76%，在未喷洒过农药的村庄居住的人群中这一比例为50%。生化参数比较显示，38%的喷雾器操作人员胆固醇降低超过150毫克%，58%的人白蛋白与球蛋白比例发生改变。其他生化指标与对照人群无显著差异。α、β和γ异构体的平均残留量以及α、β和γ异构体总量分别为0.0317、0.2254、0.0288和0.2859毫克/升；对照人群中的相应平均值分别为0.0211、0.1112、0.0197和0.1520毫克/升。喷雾器操作人员的值是普通人群的两倍。在喷雾器操作人员的暴露时长与他们血液中的胆固醇和六氯环己烷异构体水平之间观察到显著关联（p < 0.05）。未发现喷雾器操作人员因接触六氯环己烷而出现明显发病情况。
