Luo C, Copeland N G, Jenkins N A, Edelhoff S, Disteche C, Hogan P G, Rao A
Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Gene. 1996 Nov 21;180(1-2):29-36. doi: 10.1016/s0378-1119(96)00396-4.
NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.
NFAT1（NFATp）是活化T细胞核因子（NFAT）的一种胞质成分，由单个基因编码，该基因定位于小鼠2号染色体上靠近消瘦（wst）基因座的位置。尽管消瘦小鼠表现出严重的免疫紊乱，但它们表达正常水平的NFAT1蛋白。消瘦小鼠中的NFAT1蛋白受到适当调节，并且具有与其同窝对照相当的DNA结合活性。因此，消瘦表型并非由于NFAT1蛋白表达或早期调节缺陷所致。
