Soloff E V, Herzog C R, You M
Department of Pathology, Medical College of Ohio, Toledo 43699, USA.
Gene. 1996 Nov 21;180(1-2):213-5. doi: 10.1016/s0378-1119(96)00410-6.
We have PCR-amplified and sequenced the immediate (841 bp) 5'-flanking region of murine p16INK4a (MTS1, CDKN2) tumor suppressor gene. Comparing to recently published 5'-flanking region of the human alpha form of p16INK4a, homologies were found in several regions of murine p16INK4a-alpha putative promoter sequence.
我们对小鼠p16INK4a(MTS1,CDKN2)肿瘤抑制基因紧邻的(841 bp)5'侧翼区域进行了聚合酶链反应(PCR)扩增和测序。与最近发表的人类p16INK4aα型的5'侧翼区域相比,在小鼠p16INK4aα型推定启动子序列的几个区域发现了同源性。