间氯苯基哌嗪对大鼠脑内3,4-二羟基苯乙酸浓度的双相作用。
Biphasic effects of m-chlorophenyl-piperazine on 3,4-dihydroxyphenylacetic acid concentration in rat brain.
作者信息
Fuller R W, Snoddy H D
出版信息
Res Commun Chem Pathol Pharmacol. 1977 Jul;17(3):551-4.
PMID:897345
Abstract
m-Chlorophenyl-piperazine dihydrochloride injected i.p. into rats caused a rapid increase and a subsequent decrease in whole brain concentration of 3,4-dihydroxyphenylacetic acid (DOPAC), a metabolite of dopamine. The increase in DOPAC at 30 min and the decrease at 3 hrs were dose-related and occurred after doses as low as 5 mg/kg of m-chlorophenyl-piperazine dihydrochloride.
摘要
腹腔注射盐酸间氯苯哌嗪可使大鼠全脑多巴胺代谢物3,4-二羟基苯乙酸（DOPAC）的浓度迅速升高，随后下降。给药30分钟时DOPAC浓度升高，3小时时下降，且均与剂量相关，低至5mg/kg盐酸间氯苯哌嗪即可出现上述变化。
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