Catecholamine-sensitive adenylate cyclase of human fat cell ghosts. Inhibition of isoproterenol-stimulation by dihydroergotamine.

Isoproterenol-activation of the adenylate cyclase system of human fat cell ghosts was markedly inhibited by dihydroergotamine which had no effect on basal and NaF-stimulated enzyme activity. Our results indicate that the antilipolytic action of this substance in human adipose tissue is probably due to inhibition of catecholamine-sensitive adenylate cyclase activity.