Le A D, Sellers E M
Addiction Research Foundation, Canada.
Alcohol Alcohol Suppl. 1994;2:545-9.
Previous studies have shown that naltrexone and ondansetron, an opiate and 5-HT3 receptor antagonist respectively, can reduce alcohol self-administration. In the present study, we have shown a synergistic interaction between naltrexone and ondansetron in reducing alcohol intake in mice and rats. Small doses of ondansetron and naltrexone which are essentially ineffective on their own, produce powerful suppression of alcohol intake when given together. Although the exact mechanisms underlying this synergistic interaction remain to be explored, the combined use of these agents might have potential clinical importance.
先前的研究表明，纳曲酮和昂丹司琼，分别为阿片类药物和5-羟色胺3（5-HT3）受体拮抗剂，能够减少酒精的自我给药量。在本研究中，我们已经证明纳曲酮和昂丹司琼在减少小鼠和大鼠酒精摄入量方面存在协同作用。小剂量的昂丹司琼和纳曲酮单独使用时基本无效，但联合使用时能有效抑制酒精摄入量。尽管这种协同作用的确切机制仍有待探索，但这些药物的联合使用可能具有潜在的临床意义。
