Gómez-Tortosa E, Arias Navalón J A, del Barrio Alba A, Barroso Fernández T, Pardo Pardo C, Sánchez Martín J A, García Yébenes J
Servicio de Neurología, Fundación Jiménez Díaz., Madrid.
Neurologia. 1996 Aug-Sep;11(7):251-6.
The aim of this study was to trace the possible relation between degree of cognitive impairment in Huntington's disease (HD) and cortical cerebral blood flow. We studied 18 patients with genetically confirmed HD, evaluating clinical signs and performance on neuropsychological tests. SPECT with 99mTc-HMPAO was used to quantify regional cerebral blood flow (rCBF) in 8 regions in each hemisphere. We found no correlation between clinical or cognitive variables and rCBF in temporal, parietal or occipital areas. Cognitive performance on several tasks correlated significantly with rCBF (p < 0.05 or p < 0.01) in numerous frontal areas with the exception of orbital gyri. These data suggest that frontal lobe dysfunction is implicated in the pathogenesis of cognitive impairment in HD, and that such impairment can be explained by the involvement of frontal-subcortical loops.
本研究的目的是探寻亨廷顿舞蹈症（HD）认知障碍程度与大脑皮质脑血流量之间的可能关系。我们研究了18例经基因确诊的HD患者，评估其临床症状及神经心理学测试表现。使用99mTc-HMPAO单光子发射计算机断层扫描（SPECT）对每个半球的8个区域的局部脑血流量（rCBF）进行量化。我们发现临床或认知变量与颞叶、顶叶或枕叶区域的rCBF之间无相关性。除眶回外，多项任务的认知表现与多个额叶区域的rCBF显著相关（p < 0.05或p < 0.01）。这些数据表明额叶功能障碍与HD认知障碍的发病机制有关，且这种障碍可通过额叶-皮质下环路的受累来解释。
