[99mTc]tricine: a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates.
作者信息
Larsen S K, Solomon H F, Caldwell G, Abrams M J
机构信息
Johnson Matthey Pharmaceutical, West Chester, Pennsylvania 19380, USA.
出版信息
Bioconjug Chem. 1995 Sep-Oct;6(5):635-8. doi: 10.1021/bc00035a020.
PMID:8974465
Abstract
The stannous reduction of [99mTc]pertechnetate in the presence of tricine results in the formation of the new labeling precursor complex [[99m-Tc]tricine. This complex has improved efficacy for the 99mTc labeling of hydrazinonicotinate-modified IgG compared to [99mTc]glucoheptonate. FAB mass spectral analysis of the product formed by the reaction of TcOCl4 with tricine indicates the formation of TcO(tricine x 2H)2.
摘要
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