Borovskaia T G, Fomina T I, Filippova M V, Smirnova M E, Gol'dberg V E
Eksp Klin Farmakol. 1996 Mar-Apr;59(2):41-3.
The experiments performed on Wistar rats showed morphological damages of the rat testis over a one-month period after platidiam administration (4 mg/kg, one-time intravenous injection), namely a decrease in the index of spermatogenesis, in the number of normal spermatogonia, Leydig cells, and testis tubes at the 12th stage of meiosis and an increase in the number of testis tubes squamous epithelium. In the remote period (3 and 6 month after platidiam administration) the recovery of morphological and functional state of the rat testis was observed.
对Wistar大鼠进行的实验表明,在给予普拉地胺(4毫克/千克,一次性静脉注射)后一个月内,大鼠睾丸出现形态损伤,即精子发生指数降低,正常精原细胞、Leydig细胞数量减少,减数分裂第12阶段的睾丸管数量减少,而睾丸管鳞状上皮细胞数量增加。在远期(普拉地胺给药后3个月和6个月),观察到大鼠睾丸形态和功能状态的恢复。