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[对极端暴露引起的学习和记忆过程障碍的益智校正]

[The nootropic correction of disorders in learning and memory processes induced by extreme exposures].

作者信息

Iasnetsov V V, Krylova I N, Popov V M

出版信息

Eksp Klin Farmakol. 1996 May-Jun;59(3):20-3.

PMID:8974577
Abstract

Experiments on rats demonstrated that the low-intensity electromagnetic field (12.6 cm, 2375 MHz, power density 1 mW/cm2), motion sickness, and electroconvulsive shock provoked the retrograde amnesia in the passive avoidance test. The oxyracetam (100 mg/kg, i.p.), aniracetam (50 mg/kg, i.p.), nooglutil (50 mg/kg, i.p.), meclofenoxate (50 mg/kg, i.p.), pyracetam (200 mg/kg, i.p.), and GABA (200 mg/kg, i.p) prevented the memory-impairing effect of all these extreme factors. On the contrary, the N-acetylglycinamide, semax, and other nootropic drugs were effective only under one or two extreme conditions.

摘要

对大鼠的实验表明,低强度电磁场(12.6厘米,2375兆赫,功率密度1毫瓦/平方厘米)、晕动病和电惊厥休克在被动回避试验中引发了逆行性遗忘。奥拉西坦(100毫克/千克,腹腔注射)、阿尼西坦(50毫克/千克,腹腔注射)、脑复新(50毫克/千克,腹腔注射)、氯酯醒(50毫克/千克,腹腔注射)、吡拉西坦(200毫克/千克,腹腔注射)和γ-氨基丁酸(200毫克/千克,腹腔注射)可防止所有这些极端因素对记忆的损害作用。相反,N-乙酰甘氨酰胺、赛美克斯和其他促智药物仅在一两种极端条件下有效。

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