[Immunotoxicity assessment in the preclinical study of biologically active compounds].
作者信息
Uteshev B S, Arzamastsev E V
出版信息
Eksp Klin Farmakol. 1996 May-Jun;59(3):3-8.
PMID:8974580
Abstract
The immunotropic action of different drugs was considered on the basis of the modern theory of immunity (theory of network regulation). The immunosuppression and immunostimulation effects were analyzed retrospectively, as well as "disordered" immunity under the action of drugs. A systemic immunomodulated action of different drugs was postulated. Methodical recommendations for the preclinical estimation of immunotoxicity were generalized. A new protocol was proposed, concerning the examination of drug effects on the immune system.
摘要
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