[Effect of physical load deficiency on the system of calcium transport in the sarcoplasmic reticulum of skeletal muscles amd myocardium].

The authors have obtained data characterizing the changes in Ca-transporting function of sarcoplasmatic reticulum (SR) of the skeletal muscles varying in type of muscle fibers as well as the cardiac muscle of the rats during their suspension at an angle of inclination of the upper end of the body of 30 degrees and with the gravity load relief of the hind limbs. Making wide use of the available literature data on the role of Ca2+ as a secondary mediator of cellular homeostasis the authors discuss the possible mechanisms of changing the function of Ca-transporting system of the reticulum directed, by this means, the way of further studies of the transport function of Ca-ATP-ase of the membranes of SR while investigating the effects of weightlessness.