Suppression of motor cortical excitability by magnetic stimulation of the cerebellum.

EMG responses of the relaxed right thenar muscle evoked by magnetic stimulation over the sensorimotor cortex were suppressed by magnetic conditioning stimulation over the occiput. The optimal interstimulus interval for reduction of the EMG amplitude was 4-6 ms. The optimal conditioning position and induced current direction were 3-4 cm below the inion when the induced current in the center of the figure-8 coil flowed from right to left horizontally. It differed from that for activating the descending motor pathway. We consider this suppression to be due to the inhibition of motor cortex excitability caused by stimulation of the dentato-thalamo-cortical pathway at the dentate nuclei or superior cerebellar peduncle.