Schabel A, König A L, Brand U, Schnaidt M, Sugg U
Institut für Transfusionsmedizin, Katharinenhospital, Stuttgart, Deutschland.
Beitr Infusionsther Transfusionsmed. 1996;33:156-9.
Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunisation against a paternal antigen on fetal platelets. The antigen involved in the majority of cases is HPA-1 a (PIA1). Usually circulating platelet alloantibodies are detectable in the mother. In this report, we present a thrombocytopenic newborn with severe hemorrhagic diathesis due to materno-fetal HPA-1 a (PIA1) incompatibility. Platelet antibodies could initially not be demonstrated in the mother's serum but became detectable after four weeks. Because of the severe and protracted course of the disease, repeated platelet substitution was necessary throughout the first two months of life.
新生儿同种免疫性血小板减少症（NAIT）是由母体针对胎儿血小板上父源性抗原产生免疫反应所致。大多数病例中涉及的抗原是血小板特异性抗原1a（PIA1）。通常可在母亲体内检测到循环血小板同种抗体。在本报告中，我们介绍了一名因母婴血小板特异性抗原1a（PIA1）不相容而患有严重出血性素质的血小板减少症新生儿。最初在母亲血清中未检测到血小板抗体，但四周后可检测到。由于疾病病程严重且迁延，在生命的头两个月里需要反复进行血小板替代治疗。
