Grippo J
División de Neurología, Hospital de Niños R. Gutièrrez, Buenos Aires, Argentina.
Rev Neurol. 1996 Nov;24(135):1435-40.
New advances in the knowledge on the physiopathogenesis of epilepsy and their relationship with sodium and calcium channels and with the excitatory and inhibitory neurotransmitters actions have recently been developed. These knowledges have produced the research on new antiepileptic drugs which action places have specially based on the known impaired mechanisms. As the conventional drugs, the new therapeutic tool have produced a great advance in the therapy of epileptic events, specially in the refractory seizures, which represent 25-30% of the whole group of epilepsies. In the present work, we review the new drugs, ones have been registered, in order to their pharmacological properties, their efficacy their safety and their clinical indications as first-election or adjuvant drugs. We also discuss their known side adverse effects.
近年来，癫痫发病机制的知识取得了新进展，及其与钠通道、钙通道以及兴奋性和抑制性神经递质作用的关系也得到了深入研究。这些知识推动了新型抗癫痫药物的研发，其作用靶点主要基于已知的受损机制。与传统药物一样，这种新型治疗手段在癫痫发作的治疗方面取得了巨大进展，尤其是在难治性癫痫发作的治疗上，难治性癫痫发作占癫痫总病例数的25%-30%。在本研究中，我们回顾了已注册的新型药物，探讨了它们的药理特性、疗效、安全性以及作为一线或辅助药物的临床适应证。我们还讨论了其已知的不良副作用。
