[来自酿酒酵母的诱变基因。HIM基因与HSM基因之间的相互作用]

[Mutator genes from Saccharomyces cerevisiae. Interaction between HIM- and HSM-genes].

作者信息

Koval'tsova S V, Gracheva L M, Evstiukhina T A, Fedorova I V, Korolev V G

出版信息

Genetika. 1996 Jul;32(7):927-32.

Abstract

The interaction of six mutator genes of the yeast Saccharomyces cerevisiae with respect to UV-induced mutagenesis was studied. To this effect, double mutants with a genotype containing pairs of mutations at genes analyzed were synthesized. Analysis of the type of interaction of these mutations revealed four epistatic gene groups: (1) HIM1, HSM3, and HSM6; (2) HSM1; (3) HSM2; and (4) HIM2 and HIM3. The possible role of genes studied in different repair pathways of mispaired bases was discussed.

摘要

研究了酿酒酵母六个诱变基因在紫外线诱导诱变方面的相互作用。为此，合成了基因型为在所分析基因处含有成对突变的双突变体。对这些突变相互作用类型的分析揭示了四个上位基因组：(1) HIM1、HSM3和HSM6；(2) HSM1；(3) HSM2；以及(4) HIM2和HIM3。讨论了所研究基因在错配碱基不同修复途径中的可能作用。

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