Bauer J
Abteilung für Psychiatrie und Psychotherapie, Universität Freiburg/Br.
Fortschr Med. 1996 Sep 10;114(25):297-302.
While mental disorders in the elderly can often be treated by non-medical means, suicidal ideation or agitation may require the use of psychotropic agents. Since pharmacokinetics and pharmacodynamics change with increasing age of the patient, there are a number of particular features of the use of psychotropic drugs in the elderly that urgently need to be taken into account. Geriatric patients usually require only about one-half the dose needed by younger patients, and not only the side effects of psychotropic drug treatment but also, and in particular, possible interactions with other medications must also receive appropriate consideration.
虽然老年人的精神障碍通常可以通过非药物手段治疗,但自杀念头或躁动可能需要使用精神药物。由于药代动力学和药效学随患者年龄增长而变化,老年人使用精神药物有许多特殊情况迫切需要考虑。老年患者通常只需约为年轻患者所需剂量的一半,不仅要适当考虑精神药物治疗的副作用,而且尤其要考虑与其他药物可能的相互作用。