Cattaneo F, Bisaz E, Cattaneo A B, Lüthy C, Laux-End R, Bianchetti M G
Unité de néphrologie, Hôpital de l'Ile, Berne.
Nephrologie. 1996;17(6):329-32.
Formulae for estimating glomerular filtration rate with the use of body size, circulating creatinine, and an empirically derived constant are widely used. The aim of the present study was to determine whether these formulae enable accurate prediction of glomerular filtration measured from the labeled ethylenediaminetetraacetic acid in 843 pediatric patients. Bland-Altman analysis was performed on the measured glomerular filtration rate and that estimated using the constant developed in our laboratory. Age and sex of the 843 patients failed to consistently influence the empirically derived constant. Measured and estimated glomerular filtration rate were on the average identical. However, the 95% limits of agreement of the measured glomerular filtration rate with that estimated were wide (measured over estimated glomerular filtration from 0.53 to 2.04). Use of height to creatinine formulae to estimate glomerular filtration is therefore frequently insufficiently accurate.
利用体型、循环肌酐水平以及一个根据经验得出的常数来估算肾小球滤过率的公式被广泛使用。本研究的目的是确定这些公式能否准确预测843名儿科患者通过标记乙二胺四乙酸测得的肾小球滤过率。对测得的肾小球滤过率和使用我们实验室得出的常数估算的肾小球滤过率进行了布兰德-奥特曼分析。843名患者的年龄和性别未能持续影响根据经验得出的常数。测得的和估算的肾小球滤过率平均相同。然而，测得的肾小球滤过率与估算值的95%一致性界限较宽（测得值超过估算的肾小球滤过率从0.53到2.04）。因此，使用身高与肌酐公式来估算肾小球滤过率往往不够准确。
