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克霉唑联合手术治疗血清阳性和艾滋病患者复发性肛门与生殖器湿疣的症状疗效

[Symptomatic efficacy of clotrimazole combined with surgery in the treatment of recurring anal and genital condylomatosis in seropositive and AIDS patients].

作者信息

Erenbourg L, Capasso G

机构信息

Divisione di Chirurgia I, Ospedale San Raffaele-Milano.

出版信息

Minerva Med. 1996 Sep;87(9):433-5.

PMID:8975183
Abstract

During their daily surgical activity in Hiv-positive and AIDS patients the authors have seen in surgical treatment of anogenital recurring acuminate condylomata (treated with diatermocoagulation) in 1995 that prescribing elotrimazole ointment in Candida albicans infection of the same regions there was and amelioration or the healing of the mycotic infection but also a net lowering of the condylomata and persistent latency (disease-free time) till to the next local recurrence. So they have hypothesized and antiviral and antiblastic effect of elotrimazole. Under this heading they have done a literature research discovering that in 1995, only some months ago, two fundamental works have been published on this intriguing topic. They demonstrate at an experimental level in mice a strong antiviral and antiblastic activity of clotrimazole. This new fascinating field is completely open to future research and the consequences at a therapeutic level will be of utmost importance.

摘要

在对艾滋病毒阳性和艾滋病患者进行日常外科手术治疗期间,作者于1995年在对肛门生殖器复发性尖锐湿 疣(采用透热凝固法治疗)的手术治疗中发现,在同一区域白色念珠菌感染时开具克霉唑软膏,不仅霉菌感染得到改善或治愈,而且尖锐湿疣明显减少并持续处于潜伏期(无病期)直至下次局部复发。因此,他们推测克霉唑具有抗病毒和抗增殖作用。在此标题下,他们进行了文献研究,发现就在1995年,仅在几个月前,就有两篇关于这个有趣主题的重要论文发表。这些论文在小鼠实验水平上证明了克霉唑具有强大的抗病毒和抗增殖活性。这个全新的迷人领域完全有待未来的研究去探索,其在治疗层面的影响将极其重要。

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