Reshetniak V K, Kukushkin M L, Ovechkin A M, Smirnova V S, Gnezdilov A V
Laboratory of Pathophysiology of Pain, Institute of Common Pathology and Pathophysiology RAMN, Moscow.
Anesteziol Reanimatol. 1996 Jul-Aug(4):4-7.
Changes in the somatosensory evoked potentials (SSEP) were studied in patients with amputated limbs with and without phantom pain syndrome (PPS). Patients with PPS were found to develop hypersynchronous postdischarges following the components of SSEP, the amplitudes of the early components of SSEP (N1, P2, and N2) increase in response to stimulation of the stump nerves and the median nerve on the side of amputation, and EEG shows paroxysmal activity. The results indicate a stable increase of the excitability and reactivity of the central structures of the brain, reflecting the formation of a pathologic algic system in the structures regulating pain sensitivity.
对有或无幻肢痛综合征（PPS）的截肢患者的体感诱发电位（SSEP）变化进行了研究。发现患有PPS的患者在SSEP各成分之后出现超同步放电后发放，刺激残端神经和截肢侧正中神经时，SSEP早期成分（N1、P2和N2）的波幅增加，脑电图显示阵发性活动。结果表明大脑中枢结构的兴奋性和反应性稳定增加，反映了在调节疼痛敏感性的结构中病理性疼痛系统的形成。
