己烯雌酚的致癌性：非基因毒性机制的结构证据。
The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism.
作者信息
Cunningham A, Klopman G, Rosenkranz H S
机构信息
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
出版信息
Arch Toxicol. 1996;70(6):356-61. doi: 10.1007/s002040050285.
PMID:8975634
Abstract
An analysis of the structure of diethylstilbestrol (DES) indicates that neither DES nor any of its metabolites are potential mutagens. Moreover, the present analyses suggest (a) that the observed carcinogenic spectrum of DES reflects the activity of metabolic intermediates and (b) that the carcinogenicity of DES in mice is due to the presence of a 6 A geometric descriptor that appears to be related to an estrogen receptor.
摘要
己烯雌酚（DES）的结构分析表明，DES及其任何代谢产物都不是潜在的诱变剂。此外，目前的分析表明：（a）观察到的DES致癌谱反映了代谢中间体的活性；（b）DES在小鼠体内的致癌性归因于存在一个似乎与雌激素受体相关的6A几何描述符。
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