人类热休克蛋白40（Hsp40）基因（HSPF1）的基因组克隆及其在染色体上定位于19p13.2。

Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2.

作者信息

Hata M, Okumura K, Seto M, Ohtsuka K

机构信息

Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, 464, Japan.

出版信息

Genomics. 1996 Dec 15;38(3):446-9. doi: 10.1006/geno.1996.0653.

DOI:10.1006/geno.1996.0653

PMID:8975727

Abstract

The Hsp40 (heat shock protein with molecular size of approximately 40 kDa) is one of the mammalian homologues of bacterial DnaJ heat shock protein. We have isolated and characterized a genomic DNA clone encompassing the entire coding sequences of the human Hsp40 cDNA. The Hsp40 gene (HGMW-approved symbol HSPF1) is composed of three exons divided by two introns. The 5' region of the gene is highly GC rich, and there are multiple basal elements for transcription factors including typical heat shock elements. The Hsp40 gene has been assigned to chromosome 19 band p13.2 by in situ hybridization.

摘要

热休克蛋白40（分子大小约为40 kDa的热休克蛋白）是细菌DnaJ热休克蛋白的哺乳动物同源物之一。我们已经分离并鉴定了一个包含人类热休克蛋白40 cDNA完整编码序列的基因组DNA克隆。热休克蛋白40基因（经人类基因组命名委员会批准的符号为HSPF1）由三个外显子和两个内含子组成。该基因的5'区域富含GC，并且有多个转录因子的基础元件，包括典型的热休克元件。通过原位杂交，热休克蛋白40基因已被定位到19号染色体p13.2带。