[按需吸入干燥氧气对鼻黏膜纤毛清除功能的影响]

[Effect of on-demand inhalation of dry oxygen on nasal mucociliary clearance].

作者信息

Nakamura S, Mori Y, Takizawa J, Kawakami M

机构信息

Department of Pneumology, Tokyo Metropolitan Hiroo General Hospital, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Nov;34(11):1189-93.

PMID:8976072

Abstract

AIM

To determine whether nasal mucociliary clearance is affected by dry oxygen delivered on demand.

METHODS

Saccharin nasal transit time was measured as an index of nasal mucociliary clearance. One group of patients was given dry oxygen via a nasal cannula and a demand delivery system, and another group was given dry oxygen by continuous inhalation. In each group, continuous inhalation of humidified oxygen served as the control. Saccharin transit time was measured before and after 8 hours of oxygen inhalation.

SUBJECTS

The subjects were 25 patients with chronic respiratory failure who were receiving home oxygen therapy via nasal cannula. All the subjects were clinically stable (age 72.1, mean +/- SE), %VC 46.6 +/- 3.0. FEV/FVC% 9.0 +/- 1.5, PaO2 55.7 +/- 2.0 Torr. PaCO2 53.9 +/- 1.9 Torr).

RESULTS

Saccharin transit time after inhalation of dry oxygen on demand did not differ from that after continuous inhalation of humidified oxygen (15.6 +/- 1.5 vs 14.9 +/- 1.4 min). Saccharin transit time after continuous inhalation of dry oxygen was significantly lower than that after continuous inhalation of humidified oxygen (26.6 +/- 5.4 vs 16.7 +/- 2.6 min. p > 0.05).

CONCLUSION

We conclude that using the demand oxygen delivery system with a nasal cannula for 8 hours had no adverse effects on nasal mucociliary clearance.

摘要

目的

确定按需提供的干燥氧气是否会影响鼻黏液纤毛清除功能。

方法

测量糖精经鼻转运时间作为鼻黏液纤毛清除功能的指标。一组患者通过鼻导管和按需输送系统给予干燥氧气，另一组患者通过持续吸入给予干燥氧气。每组中，持续吸入湿化氧气作为对照。在吸氧8小时前后测量糖精转运时间。

研究对象

研究对象为25例通过鼻导管接受家庭氧疗的慢性呼吸衰竭患者。所有研究对象临床状况稳定（年龄72.1，均值±标准误），肺活量百分比（%VC）为46.6±3.0，第一秒用力呼气容积与用力肺活量比值（FEV/FVC%）为9.0±1.5，动脉血氧分压（PaO2）为55.7±2.0托，动脉血二氧化碳分压（PaCO2）为53.9±1.9托。