Naitoh T, Matsushita K, Asai Y, Suetsugu S
Department of Internal Medicine, School of Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Nov;34(11):1260-3.
A 15-year-old boy had metastasis to the spinal cord and then to the lung after an operation to remove a primary medulloblastoma. A medulloblastoma developed at the age of 10 years. The tumor was completely resected and the brain and spinal cord were irradiated. At the age of 13 years, metastasis to the sacral spinal cord developed and was treated with radiotherapy and intramedullary injection of methotrexate. At the age of 15 years, metastasis to the lung developed and was treated with chemotherapy (CBDCA, VP-16) followed by radiotherapy. Three months after the end of that therapy, the disease recurred but another course of radiotherapy and chemotherapy (VCR) was successful. Chemotherapy and radiotherapy were effective against metastatic lesions of medulloblastoma. With improvement in the survival rate among patients with medulloblastoma, we can expect incidence of extraneural metastases to increase. In addition to recurrence of the primary lesion and intramedullary dissemination, these metastatic lesions also require attention.
一名15岁男孩在接受原发性髓母细胞瘤切除手术后，发生了脊髓转移，随后又出现了肺部转移。该男孩10岁时患上髓母细胞瘤，肿瘤被完全切除，脑部和脊髓接受了放射治疗。13岁时，骶部脊髓出现转移，接受了放射治疗和甲氨蝶呤髓内注射治疗。15岁时，肺部出现转移，接受了化疗（顺铂、依托泊苷），随后进行了放射治疗。该治疗结束三个月后，疾病复发，但另一疗程的放射治疗和化疗（长春新碱）取得了成功。化疗和放疗对髓母细胞瘤的转移病灶有效。随着髓母细胞瘤患者生存率的提高，我们预计神经外转移的发生率会增加。除了原发灶复发和髓内播散外，这些转移病灶也需要引起关注。
