Yamanaka H
Institute of Rheumatology, Tokyo Women's Medical College.
Nihon Rinsho. 1996 Dec;54(12):3261-5.
Two classes of urate lowering agents, i.e. uricosuric agents and allopurinol, are available for the treatment of hyperuricemia. To prevent the formation of urinary urate stones and possible damage to liver function, it is recommended to use uricosuric agents in those patients with underexcretion of urate, and allopurinol in those with overproduction. Urinary uric acid/creatinine ratio is a convenient index to determine these phenotypes. These agents should be started to prescribe from the minimal dose to prevent the gouty arthritis which is easily evoked in the first several months after the introduction of these agents. An uric acid level between 5.0 and 6.4 mg/dl had minimal occurence of gouty attack during the first six months of the drug therapy.
有两类降尿酸药物，即促尿酸排泄药和别嘌醇，可用于治疗高尿酸血症。为预防尿酸结石形成及可能的肝功能损害，推荐在尿酸排泄减少的患者中使用促尿酸排泄药，在尿酸生成过多的患者中使用别嘌醇。尿尿酸/肌酐比值是确定这些表型的便捷指标。这些药物应从小剂量开始处方，以预防在开始使用这些药物后的最初几个月容易诱发的痛风性关节炎。在药物治疗的前六个月中，尿酸水平在5.0至6.4mg/dl之间时痛风发作的发生率最低。
