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作者信息

Hartl D L

机构信息

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

Bioessays. 1996 Dec;18(12):1021-3. doi: 10.1002/bies.950181213.

DOI:10.1002/bies.950181213

PMID:8976160

Abstract

A recently published study has identified a set of candidate genes for human diseases based on findings from Drosophila. Each human expressed sequence tag (EST) in a large database was compared with all known Drosophila genes. After eliminating matches between genes of already known function, the remaining sequences were mapped in the human genome. In each region, the phenotypes of all known human diseases were compared with the phenotypes of known Drosophila mutations in order to identify candidate genes for the human diseases. Are the correspondences real or coincidental?

摘要

最近发表的一项研究基于果蝇的研究结果确定了一组人类疾病的候选基因。将一个大型数据库中的每个人类表达序列标签（EST）与所有已知的果蝇基因进行比较。在排除已知功能基因之间的匹配后，将剩余序列定位到人类基因组中。在每个区域，将所有已知人类疾病的表型与已知果蝇突变的表型进行比较，以确定人类疾病的候选基因。这些对应关系是真实的还是巧合的？