Stocker S, Knüchel R, Sroka R, Kriegmair M, Steinbach P, Baumgartner R
Department of Urology, University of Munich, FRG.
J Urol. 1997 Jan;157(1):357-61.
The aim of the study was to determine photodynamic effects in chemically induced rat bladder tumors after intravesical instillations of 5-aminolevulinic acid (5-ALA) and PDT-dependence on laser wavelength and light dose.
Following intravesical instillation of a 5-ALA solution (40 mg 5-ALA in isotonic saline and sodium-bicarbonate) rat bladder tumors have been treated with integral irradiation using laser light at wavelengths of lambda = 630 nm and lambda = 635 nm in a light dose range of 15 to 100 J/cm2.
A significantly higher amount of necrosis including damage of normal urothelium was obtained in rat bladder tumors using laser light at lambda = 635 nm.
For 5-ALA assisted photodynamic treatment of superficial bladder cancer in patients the irradiation wavelength of lambda = 635 nm is recommended.
本研究的目的是确定在膀胱内灌注5-氨基乙酰丙酸（5-ALA）后，化学诱导的大鼠膀胱肿瘤中的光动力效应以及光动力疗法对激光波长和光剂量的依赖性。
在膀胱内灌注5-ALA溶液（40mg 5-ALA溶于等渗盐水和碳酸氢钠）后，使用波长为λ = 630nm和λ = 635nm的激光对大鼠膀胱肿瘤进行整体照射，光剂量范围为15至100J/cm²。
使用波长为λ = 635nm的激光时，大鼠膀胱肿瘤中出现了明显更多的坏死，包括正常尿路上皮的损伤。
对于患者浅表膀胱癌的5-ALA辅助光动力治疗，建议照射波长为λ = 635nm。
