Betts D R, Leibundgut K E, Niggli F K
Department of Oncology, Universitäts-Kinderklinik Zürich, Switzerland.
Cancer Genet Cytogenet. 1996 Dec;92(2):144-6. doi: 10.1016/s0165-4608(96)00157-4.
We report the cytogenetic analysis of a medulloepithelioma, a rare neuroectodermally-derived tumor of childhood, which to our knowledge is the first reported karyotype of this tumor. The tumor sample was received at diagnosis and was mechanically dissociated to create cell suspension cultures. The primary cytogenetic abnormality was a der(16)t(1;16) chromosome, which was typical of that reported in a wide range of other tumor types. The other abnormalities seen were a del(6q) and monosomy 15.
我们报告了一例髓上皮瘤的细胞遗传学分析，这是一种罕见的儿童神经外胚层来源肿瘤，据我们所知，这是该肿瘤首次报道的核型。肿瘤样本在诊断时获取，并通过机械解离创建细胞悬液培养物。主要的细胞遗传学异常是der(16)t(1;16)染色体，这在许多其他肿瘤类型中报道的是典型的。观察到的其他异常是del(6q)和15号染色体单体。
