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Genetic and physical mapping of the ovine cystic fibrosis gene.

作者信息

Tebbutt S J, Broom M F, van Stijn T C, Montgomery G W, Hill D F

机构信息

Department of Biochemistry, University of Otago, Dunedin, New Zealand.

出版信息

Cytogenet Cell Genet. 1996;74(4):245-7. doi: 10.1159/000134425.

DOI:10.1159/000134425
PMID:8976375
Abstract

Two yeast artificial chromosomes (YACs 48B6 and 88F7) that span the ovine cystic fibrosis transmembrane conductance regulator (CFTR) gene locus have been isolated. These YAC clones have been physically assigned to the interval 4q23-->q25 on sheep chromosome 4, using fluorescence in situ hybridization. A sequence polymorphism in exon 7 of the CFTR gene was identified in Merino sheep and present at a low frequency. This polymorphism segregated in several flocks. Linkage analysis confirmed the location of CFTR on sheep chromosome 4. The most likely location is within a 13.7-cM region close to markers MAF70 and TGLA116.

摘要

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