Swanson W H
Retina Foundation of the Southwest, Dallas, TX 75231-3303, USA.
Vision Res. 1996 Nov;36(21):3549-55. doi: 10.1016/0042-6989(96)00047-8.
Short-wavelength-sensitive (S-) cone-mediated thresholds have been used to study the early stages of visual loss, but due to the effects of non-neural factors (pupil size, lenticular density, macular pigment density) S-cone thresholds are often of limited clinical utility. The current study evaluates four possible effects of non-neural factors on S-cone contrast sensitivity, and shows how these can be minimized by measuring sensitivity for 1-5 c/deg with a range of retinal illuminances for blue test gratings on yellow backgrounds. The data are fit well with a simple four-parameter model which indicates that S-cone contrast sensitivity can be relatively independent on non-neural factors. A simple control experiment is described for evaluating the independence in individual patients.
短波敏感（S）视锥介导的阈值已被用于研究视力丧失的早期阶段，但由于非神经因素（瞳孔大小、晶状体密度、黄斑色素密度）的影响，S视锥阈值的临床应用往往有限。本研究评估了非神经因素对S视锥对比敏感度的四种可能影响，并展示了如何通过在黄色背景上用一系列视网膜照度测量1-5 c/deg的蓝色测试光栅敏感度来将这些影响最小化。数据与一个简单的四参数模型拟合良好，该模型表明S视锥对比敏感度可能相对独立于非神经因素。描述了一个简单的对照实验，用于评估个体患者的独立性。
