来自易中风自发性高血压大鼠和Wistar-Kyoto大鼠的雌性F2后代中，3号染色体上新区域与盐诱导高血压的共分离。
Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats.
作者信息
Matsumoto C, Nara Y, Ikeda K, Tamada T, Mashimo T, Nabika T, Sawamura M, Yamori Y
机构信息
Department of Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
出版信息
Clin Exp Pharmacol Physiol. 1996 Dec;23(12):1028-34. doi: 10.1111/j.1440-1681.1996.tb01163.x.
Abstract
- We investigated candidate loci for salt-sensitive high blood pressure (BP) in F2 progeny from crossing Wistar-Kyoto and stroke-prone spontaneously hypertensive rats. 2. In female F2 progeny, systolic and diastolic BP on the 12th day and the seventh month after salt loading was strongly linked with the D3Mgh12 and D3Mgh6 loci on chromosome 3, respectively. 3. These loci were linked with BP only in female F2 progeny, not in males. 4. These results indicate that hormonal factors may influence salt sensitivity, particularly with respect to gender differences.
摘要
- 我们在将Wistar-Kyoto大鼠与易中风自发性高血压大鼠杂交产生的F2后代中，研究了盐敏感性高血压（BP）的候选基因座。2. 在雌性F2后代中，盐负荷后第12天和第7个月的收缩压和舒张压分别与3号染色体上的D3Mgh12和D3Mgh6基因座紧密相关。3. 这些基因座仅在雌性F2后代中与血压相关，在雄性中则不然。4. 这些结果表明，激素因素可能影响盐敏感性，尤其是在性别差异方面。
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