Krementz E T, Sutherland C M, Muchmore J H
Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Surg Clin North Am. 1996 Dec;76(6):1313-30. doi: 10.1016/s0039-6109(05)70517-x.
Safe techniques for regional chemotherapy of the limbs by perfusion are now available. The method is effective in obtaining regionally confined high levels of toxic drugs or chemotherapeutic agents in the isolated areas. The best responses have been observed in limb melanoma with recurrent or intransit disease. Chemotherapy by perfusion as an adjunct to surgical excision reduces the local recurrence and the regional and lymph node metastases. Our survivals for adjunctive perfusion for Stage I melanomas with Level V and lesions 5 mm thick and thicker are better than usually reported. Regional chemotherapy has had an important role in reduction of major amputations for the control of limb melanoma. Multiple chemotherapeutic limb perfusions can further extent survival in patients with recurring melanoma.
目前已有肢体灌注区域化疗的安全技术。该方法能有效地在隔离区域获得局部高浓度的毒性药物或化疗药物。在复发性或移行性肢体黑色素瘤中观察到了最佳疗效。灌注化疗作为手术切除的辅助手段，可减少局部复发以及区域和淋巴结转移。对于Ⅰ期、Ⅴ级且病灶厚度达5毫米及以上的黑色素瘤患者，辅助灌注治疗的生存率高于通常报道的情况。区域化疗在减少因控制肢体黑色素瘤而进行的大截肢手术方面发挥了重要作用。多次肢体化疗灌注可进一步延长复发性黑色素瘤患者的生存期。
