Schlech W F
Dalhousie University and the Victoria General Hospital, Halifax N.S. (Canada).
Pathol Biol (Paris). 1996 Nov;44(9):775-82.
Listeriosis is primarily a foodborne disease and the pathogenesis of infection is determined by passage of the organism from the gastrointestinal lumen to the reticuloendothelial cells of the liver and spleen. Subsequent invasive events such as sepsis and meningitis develop. The immune response to Listeria is characterized by early macrophage mediated killing followed by the development of a brisk cell mediated immune response. Humoral immunity appears to play no role in infection in the protected response. Organism specific virulence factors such as hemolysin and actin polymerization factor may play important roles in pathogenesis and also illicit specific immune responses. Immunization against listeriosis has been carried in animals but does not appear feasible for this rare infection in human populations.
李斯特菌病主要是一种食源性疾病，感染的发病机制取决于该微生物从胃肠道腔进入肝脏和脾脏的网状内皮细胞。随后会发生诸如败血症和脑膜炎等侵袭性事件。对李斯特菌的免疫反应的特征是早期由巨噬细胞介导的杀伤，随后是活跃的细胞介导免疫反应的发展。体液免疫在保护性反应的感染中似乎不起作用。诸如溶血素和肌动蛋白聚合因子等特定于该微生物的毒力因子可能在发病机制中起重要作用，并且还引发特定的免疫反应。针对李斯特菌病的免疫接种已在动物身上进行，但对于人类这种罕见感染而言似乎并不可行。
