[Circadian rhythms in hepatic biotransformation of drugs].
作者信息
Bélanger P M
机构信息
Ecole de pharmacie, Pavillon Vandry, Université Laval, Québec, Canada.
出版信息
Pathol Biol (Paris). 1996 Jun;44(6):564-70.
PMID:8977913
Abstract
The temporal variations in hepatic drug biotransformation are reviewed. Important diurnal variations in the activity of different cytochrome P-450 isoenzymes and in enzyme systems involved in conjugation to glucuronide, sulfate and acetate are described. A circadian rhythm in the hepatic concentration of glutathione is also described. These temporal variations explain the chronopharmacokinetic and chronohepatotoxicity of some drugs or toxic agents.
摘要
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[Circadian rhythms in hepatic biotransformation of drugs].
Pathol Biol (Paris). 1996 Jun;44(6):564-70.
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