Scrofani A, Cioni M, Filetti S, Lanaia F, Pennisi G, Bella R, Grasso A
Istituto di Scienze Neurologiche, Università di Catania, Italy.
Ital J Neurol Sci. 1996 Dec;17(6):423-8. doi: 10.1007/BF01997717.
We investigated the effects of the somatosensitive and sensory afferent inputs on the thalamic generators of sleep spindles (SS) in adult subjects affected by posterior funiculi lesions (five subjects), deafness (four subjects) or blindness (four subjects). The density, duration and frequency of SS, as well as the index of spindling, were analyzed during stage 2 NREM. The results show that the subjects with somatosensitive and sensorial lesions spent much more time on SS activity than the control group (eight subjects), and had a significantly increased density (< .0001), duration (< .0005) and index of spindling (< .0001). On the other hand, the frequency of spindling was little modified (< .05). Moreover, among the three groups of patients, those with somatosensitive deficits showed the greatest SS activity. In conclusion, our results suggest that the thalamic generators of SS are markedly modulated by peripheral inputs in man.
我们研究了躯体感觉和感觉传入输入对患有后索病变（5名受试者）、耳聋（4名受试者）或失明（4名受试者）的成年受试者睡眠纺锤波（SS）丘脑发生器的影响。在非快速眼动睡眠第2阶段分析了SS的密度、持续时间和频率，以及纺锤波指数。结果表明，患有躯体感觉和感觉病变的受试者在SS活动上花费的时间比对照组（8名受试者）多得多，并且密度（<.0001）、持续时间（<.0005）和纺锤波指数（<.0001）显著增加。另一方面，纺锤波频率变化不大（<.05）。此外，在三组患者中，躯体感觉缺陷患者的SS活动最为明显。总之，我们的结果表明，人类SS的丘脑发生器受到外周输入的显著调节。
