Lei K I, Gwi E, Ma L, Liang E Y, Johnson P J
Department of Clinical Oncology, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Oncology. 1997 Jan-Feb;54(1):19-22. doi: 10.1159/000227655.
A case of advanced leiomyosarcoma of the urinary bladder is reported in a 25-year old man who, in a short time, experienced a complete 'spontaneous' regression of his fatal illness. He first presented with severe haemoperitoneum resulting from an unresectable bleeding tumour of the urinary bladder. Debulking surgery was performed, followed by salvage chemotherapy. Histological and ultrastructural examinations of the tumour confirmed a poorly differentiated leiomyosarcoma. The residual disease failed to respond to salvage chemotherapy, but regressed 'spontaneously' 5 months after cessation of therapy. The patient is alive without evidence of disease 51 months after the diagnosis. This remarkable phenomenon and relatively long survival in a poor-risk leiomyosarcoma of the urinary bladder has never been reported previously.
报告了一例25岁男性晚期膀胱平滑肌肉瘤病例，该患者在短时间内其致命疾病出现了完全“自发”消退。他最初表现为因无法切除的膀胱出血性肿瘤导致的严重腹腔积血。进行了减瘤手术，随后进行了挽救性化疗。肿瘤的组织学和超微结构检查证实为低分化平滑肌肉瘤。残留病灶对挽救性化疗无反应，但在治疗停止后5个月“自发”消退。诊断后51个月，患者存活且无疾病证据。这种显著现象以及高危膀胱平滑肌肉瘤患者相对较长的生存期此前从未有过报道。
