Akimoto T, Mitsuhashi N, Takahashi I, Yonome I, Takahashi M, Hayakawa K, Niibe H
Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Japan.
Oncology. 1997 Jan-Feb;54(1):23-7. doi: 10.1159/000227656.
We analyzed the treatment results of 15 patients with penile cancer treated by afterloading brachytherapy with a silicon-made mold we devised. The group included 8 patients with T1, 5 with T2 and 2 with T3 tumors, and inguinal lymph node metastases were noted in 4 patients. The total dose of brachytherapy ranged from 32 to 74 Gy with or without an electron beam boost. The median dose rate was 200 cGy/h ranging from 100 to 350 cGy/h. Local control was achieved in 12 of the 15 patients (80%), and was related to the T category, with 100% of T1 and 80% of T2, in contrast to 0% of T3 tumor. Three patients with partial response or residual tumor underwent amputation. Local recurrence was recognized in 1 patient with a T2 tumor, but salvaged by surgery. Penis conservation was achieved in 11 of 15 patients (73%). Of the 4 patients with inguinal lymph node metastases, 3 were controlled by surgery and radiation therapy. The other with a T3 tumor died from the disease. Brachytherapy with a mold for penile cancer was considered to be the first choice for penis-conserving therapy, and the patients with T1 and T2 tumors have good indications for this method of treatment.
我们分析了15例阴茎癌患者采用我们设计的硅制模具后装近距离放射治疗的结果。该组包括8例T1期、5例T2期和2例T3期肿瘤患者，4例患者有腹股沟淋巴结转移。近距离放射治疗的总剂量为32至74 Gy，有或无电子束增强。中位剂量率为200 cGy/h，范围为100至350 cGy/h。15例患者中有12例（80%）实现了局部控制，这与T类别有关，T1期为100%，T2期为80%，而T3期肿瘤为0%。3例部分缓解或有残留肿瘤的患者接受了截肢手术。1例T2期肿瘤患者出现局部复发，但通过手术挽救。15例患者中有11例（73%）实现了阴茎保留。4例有腹股沟淋巴结转移的患者中，3例通过手术和放射治疗得到控制。另1例T3期肿瘤患者死于该疾病。阴茎癌模具近距离放射治疗被认为是阴茎保留治疗的首选方法，T1期和T2期肿瘤患者对这种治疗方法有良好的适应证。
